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排序方式: 共有68条查询结果,搜索用时 109 毫秒
41.
42.
Islam Atif Yasin Tariq Akhtar Muhammad Javed Imran Zahid Sabir Aneela Sultan Misbah Khan Shahzad M. Jamil Tahir 《Journal of Solid State Electrochemistry》2016,20(2):571-578
Journal of Solid State Electrochemistry - Polymer films were cast from aqueous solutions of chitosan (CS) and poly(vinyl alcohol) (PVA) in employing tetraethoxysilane (TEOS) as a crosslinking... 相似文献
43.
44.
This contribution is concerned with the numerical modeling of an isolated red blood cell (RBC), and more generally of phospholipid membranes. We propose an adaptive Eulerian finite element approximation, based on the level set method, of a shape optimization problem arising in the study of RBCs. We simulate the equilibrium shapes that minimize the elastic bending energy under prescribed constraints of fixed volume and surface area. An anisotropic mesh adaptation technique is used in the vicinity of the cell membrane to enhance the robustness of the method. Efficient time and spatial discretizations are considered and implemented. We address in detail the main features of the proposed method, and finally we report several numerical experiments in the two‐dimensional and the three‐dimensional axisymmetric cases. The effectiveness of the numerical method is further demonstrated through numerical comparisons with semi‐analytical solutions provided by a reduced order model. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
45.
We analyze the dynamics of electromigration-induced step bunching in the absence of desorption. We show that, even when the instability occurs at long wavelength, hinting to a smooth morphology, the surface suddenly splits into bunches escorted with wide terraces, in agreement with several observations. As the size of the bunches increases, a nonstandard regime is exhibited, namely, the bunches do not match tangentially to the facet, as would the classical Pokrosvky-Talapov shape dictate. This Letter presents a complete scenario of evolution of bunches from their birth up to their ultimate stage. 相似文献
46.
E. Bonnetier C. Misbah F. Renard R. Toussaint J.-P. Gratier 《The European Physical Journal B - Condensed Matter and Complex Systems》2009,67(1):121-131
Non-planar solid-fluid-solid interfaces under stress are very common in many industrial and natural materials. For example,
in the Earth’s crust, many rough and wavy interfaces can be observed in rocks in a wide range of spatial scales, from undulate
grain boundaries at the micrometer scale, to stylolite dissolution planes at the meter scale. It is proposed here that these
initially flat solid-fluid-solid interfaces become rough by a morphological instability triggered by elastic stress. A model
for the formation of these unstable patterns at all scales is thus presented. It is shown that such instability is inherently
present due to the uniaxial stress that promotes them, owing to the gain in the total elastic energy: the intrinsic elastic
energy plus the work of the external forces. This is shown explicitly by solving the elastic problem in a linear stability
analysis, and proved more generally without having resort to the computation of the elastic field. 相似文献
47.
Nadine Leber Leonard Kaps Aiting Yang Misbah Aslam Mariacristina Giardino Adrian Klefenz Niklas Choteschovsky Sebastian Rosigkeit Asmaa Mostafa Lutz Nuhn Detlef Schuppan Rudolf Zentel 《Macromolecular bioscience》2019,19(7)
Immunosuppressive M2 macrophages govern the immunophathogenic micromilieu in many severe diseases including cancer or fibrosis, thus, their re‐polarization through RNA interference is a promising concept to support combinatorial therapies. For targeted siRNA delivery, however, safe and stable carriers are required that manage cell specific transport to M2 macrophages. Here, siRNA‐loaded cationic nanogels are reported with α‐mannosyl decorated surfaces that target and modify M2 macrophages selectively. Via amphiphilic precursor block copolymers bearing one single α‐mannosyl moiety at their chain end mannosylated cationic nanohydrogel particles (ManNP) were obtained of 20 nm diameter determined by dynamic light scattering and cryogenic electron transmission microscopy. α‐Mannosyl surface modification is confirmed by agglutination with concanavalin A. SiRNA‐loaded ManNP preferentially targets the overexpressed mannose receptor CD206 on M2 macrophages, as shown by in vitro cell uptake studies in M2 polarized primary macrophages. This specificity is confirmed, since ManNP uptake could be reduced by blocking of CD206 with mannan. Effective ManNP‐guided siRNA delivery is confirmed by sequence‐specific gene knockdown of CSF‐1R in M2‐type macrophages exclusively, while the expression levels in M1‐polarized macrophages is not affected. In conclusion, α‐mannosyl‐functionalized ManNPs are promising universal siRNA carriers for targeted immunomodulatory treatment of immunosuppressive macrophages. 相似文献
48.
The interaction between inclusions mediated by biological membranes undulations is analyzed. The interaction law is interpreted in terms of symmetries associated with inclusions. We show, in particular, that for a C3 and C3v symmetries the interaction law falls as 1/r3. We show that for completely isotropic inclusions, the dominant interaction vanishes to all orders, and the first contribution stems from the induced interaction which behaves as 1/r4. The same law holds for any other symmetry which is higher than C4. We introduce a straightforward method to compute these interactions. We point out important differences with results in the literature and explain the discrepancies. 相似文献
49.
T. Biben C. Misbah 《The European Physical Journal B - Condensed Matter and Complex Systems》2002,29(2):311-316
We study dynamics of a deformable entity (such as a vesicles under hydrodynamical constraints). We show how the problem can
be solved by means of Green's functions associated with the Stokes equations. A gauge-field invariant formulation makes the
study of dynamics efficient. However, this procedure has its short-coming. For example, if the fluids are not Newtonian, then
no Green's function is available in general. We introduce a new approach, the advected field one, which opens a new avenue
of applications. For example, non-Newtonian entities can be handled without additional deal. In addition problems like budding,
droplet break-up in suspensions, can naturally be treated without additional complication. We exemplify the method on vesicles
filled by a fluid having a viscosity contrast with the external fluid, and submitted to a shear flow. We show that beyond
a viscosity contrast (the internal fluid being more viscous), the vesicle undergoes a tumbling bifurcation, which has a saddle-node
nature. This bifurcation is known for blood cells. Indeed red cells either align in a shear flow or tumble according to whether
haematocrit concentration is high or low.
Received 19 December 2001 / Received in final form 31 May 2002 Published online 2 October 2002
RID="a"
ID="a"e-mail: chaouqi.misbah@ujf-grenoble.fr 相似文献
50.
We analyze the problem of vesicle migration in haptotaxis (a motion directed by an adhesion gradient), though most of the
reasoning applies to chemotaxis as well as to a variety of driving forces. A brief account has been published on this topic
[#!Cantat99a!#]. We present an extensive analysis of this problem and provide a basic discussion of most of the relevant processes
of migration. The problem allows for an arbitrary shape evolution which is compatible with the full hydrodynamical flow in
the Stokes limit. The problem is solved within the boundary integral formulation based on the Oseen tensor. For the sake of
simplicity we confine ourselves to 2D flows in the numerical analysis. There are basically two regimes (i) the tense regime
where the vesicle behaves as a “droplet” with an effective contact angle. In that case the migration velocity is given by
the Stokes law. (ii) The flask regime where the vesicle has a significant (on the scale of the vesicle size) contact curvature.
In that case we obtain a new migration law which substantially differs from the Stokes law. We develop general arguments in
order to extract analytical laws of migration. These are in good agreement with the full numerical analysis. Finally we mention
several important future issues and open questions.
Received 24 June 2002 and Received in final form 4 February 2003 Published online: 16 April 2003
RID="a"
ID="a"e-mail: isabelle.cantat@univ-rennes1.fr 相似文献